WDR5 Protein(W325-30H)

WDR5 Protein(W325-30H)

  • $215.00


Description :Full-length recombinant human WDR5 was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :His tag

Expression System:E.coli

Sequence :Full length

Genbank Number :BC001635

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :~40 kDa

Gene Aliases :BIG3; BIG-3

Scientific Background :WD repeat-containing protein 5 (WDR5) is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes. Selectively binds dimethylated Lys4 (K4me2) in histone H3 to promote K4 trimethylation by TRX.

References :
1. Couture JF, et al: Molecular recognition of histone H3 by the WD40 protein WDR5. Nat Struct Mol Biol. 2006 13(8):698-703.

2. Han Z, et al: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol Cell. 2006 22(1):137-44.

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Research Areas :Cancer, Inflammation, Metabolic Disorder