Troponin1 Protein(T68-30H)

Troponin1 Protein(T68-30H)

  • $215.00


Description :Recombinant full-length human Troponin1 protein was expressed in E. coli cells using an N-terminal His tag.

Species :Human

Tag :HIS tag

Expression System:E.coli

Sequence :Full Length

Genbank Number :NM_003281

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~24 kDa

Gene Aliases :TNNI1; DKFZp451O223; SSTNI; TNN1

Scientific Background :Troponin1 is a member of the tropomyosin family and regulates the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin1 is part of a complex with troponin T and troponin C in which Troponin1 acts as an inhibitory subunit that blocks actin-myosin interactions and thereby mediates striated muscle relaxation (1). Troponin1 is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The Troponin1 protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes (2).

References :
1. Tiso, N. et al: Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast. Biochem. Biophys. Res. Commun. 230: 347-350, 1997.

2. al: Molecular basis of cardiac performance: plasticity of the myocardium generated through protein isoform switches. J. Clin. Invest. 84: 1693-1700,198

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Research Areas :Cardiovascular Disease, Cardiovascular Disease