TRIB1 Protein(T30-30G)

TRIB1 Protein(T30-30G)

  • $215.00


Description :Recombinant full-length human TRIB1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_025215

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~70 kDa

Gene Aliases :C8FW; GIG2; SKIP1; TRB1

Scientific Background :TRIB1 or tribbles homolog 1 protein encodes one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB1 is highly expressed in skeletal muscle, thyroid, pancreas, peripheral blood leukocytes, and bone marrow. The overexpression of TRIB1 may be functionally important consequence of 8q24 amplicons in AML and MDS (1). TRIB1 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2).

References :
1. Storlazzi, C. Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignancies. Hum. Molec. Genet. 13: 1479-1485, 2004.

2. Wu, M. SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.

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Research Areas :Cancer, Metabolic Disorder, Cancer, Metabolic Disorder