SETD6, Active(S355-380G)
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Description :Recombinant full-length human SETD6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_001160305
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :75 kDa
Gene Aliases :None
Scientific Background :SET domain-containing protein 6 (SETD6) is a mono-methyltransferase that has been shown to methylate RelA of NF-kappa-B complex and thus attenuate NF-kappa-B transcription factor activity. In addition, it monomethylates the histone H2A variant H2AZ which is required for the maintenance of embryonic stem cell self-renewal.
References :
1. Levy D, et al: Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyl-transferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol. 2011 12(1):29-36.
2. Binda O, et al: SETD6 monomethylates H2AZ on lysine 7 and is required for the maintenance of embryonic stem cell self-renewal. Epigenetics. 2013 8(2):177-83.
Product Sheets (By Lot #) :
Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology