SUV420H1 (KMT5B), Active(S351-380G)

SUV420H1 (KMT5B), Active(S351-380G)

  • $259.00


Description :Recombinant full-length human SUV420H1 (KMT5B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :BC103498

Specific Activity :Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :160 kDa

Gene Aliases :KMT5B, CGI-85, MGC21161, MGC703

Scientific Background :Histone-lysine N-methyltransferase, Suppressor of variegation 4-20 homolog 1 SUV420H1 specifically trimethylates 'Lys-20' of histone H4, which in turn acts as a specific tag for epigenetic transcriptional repression. Located in pericentric heterochromatin regions, and plays a central role in the establishment of constitutive heterochromatin in these regions. Interacts with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases) mediated by its SET domains.

References :
1. Tryndyak VP, et al: Loss of DNA methylation and histone H4 lysine 20 trimethylation in human breast cancer cells is associated with aberrant expression of DNA methyl-transferase 1, Suv4-20h2 histone methyltransferase and methyl-binding proteins. Cancer Biol Ther. 5(1):65-70, 2006.

2. Lai CH, et al: Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Genome Res. 10(5):703-13, 2000.

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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology