SETD1A (KMT2F), Active(S342-381G)

SETD1A (KMT2F), Active(S342-381G)

  • $259.00


Description :Recombinant human SETD1A (1418-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tags

Expression System:Sf9 insect cells using baculovirus

Sequence :1418-end

Genbank Number :NM_014712

Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Methyltransferase Assay

Molecular Weight :61 kDa

Gene Aliases :SETD1A; KMT2F; Set1; Set1A

Scientific Background :As a member of the mixed lineage leukemia (MLL) family of histone methyltransferase, it specifically methylates 'Lys-4' of histone H3, when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation.

References :
1. Li Y, et al: Structural basis for activity regulation of MLL family methyltransferases. Nature. 530(7591):447-52. 2016


Product Sheets (By Lot #) :


Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology