STK16 Protein(S31-34G)
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Description :Recombinant full-length human STK16 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_003691
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~58 kDa
Gene Aliases :KRCT, MPSK, TSF1, PKL12, FLJ39635
Scientific Background :STK16 is serine/threonine kinase 16 which constitute the catalytic subunit of a multisubunit kinase. STK16 is ubiquitously expressed at very low levels and expression of an STK16 fusion protein showed that STK16 is localized with Golgi and Golgi-derived vesicles. The overexpression of STK16 leads to disorganization of the Golgi apparatus into vesicular structures and STK16 is highlyinvolved in the secretory pathway (1). STK16 is involved in the transforming growth factor (TGF)-beta signalling pathway (2).
References :
1. Ligos, J. M. et.al: Cloning, expression analysis, and functional characterization of PKL12, a member of a new subfamily of ser/thr kinases. Biochem. Biophys. Res. Commun. 249: 380-384, 1998.
2. Ohta, S. et.al: A novel transcriptional factor with Ser/Thr kinase activity involved in the transforming growth factor (TGF)-beta signalling pathway. Biochem. J. 350: 395-404, 2000.
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Research Areas :Cardiovascular Disease, ERK/MAPK Pathway, Neurobiology, PKA/PKC Pathway, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, PKA/PKC Pathway, Ser/Thr Kinases