SOD1 Protein (S26-30G)

SOD1 Protein (S26-30G)

  • $215.00


Description : Recombinant full-length human SOD1 was expressed in E. coli cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : E.coli

Sequence : Full Length

Genbank Number : NM_000454

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : ~45 kDa

Gene Aliases : Cu/Zn-SOD, ALS, SOD, ALS1, IPOA, Homodimer, Superoxide Dismutase 1

Scientific Background :  SOD1 (superoxide dismutase 1) is the major soluble cytoplasmic enzyme responsible for destroying harmful free superoxide radicals in the body thereby providing defence against oxygen free-radical toxicity. Soluble cytoplasmic SOD1 is a copper- and zinc-containing enzyme and the SOD1 gene maps to chromosome 21q22 (1). Mutations in the SOD1 gene have been implicated to be the cause of familial amyotrophic lateral sclerosis, increased age-related muscle mass loss, early development of cataracts, macular degeneration, thymic involution, hepatocellular carcinoma, and shortned lifespan (2).

References : 
1. Sherman, L. et al: Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA. Proc. Nat. Acad. Sci. 80: 5465-5469, 1983.

2. Al-Chalabi, Ammar, Recent advances in amyotrophic lateral sclerosis". Current Opinion in Neurology, 2000, 13 (4): 397–405.

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Research Areas : Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology,