PDE6D Protein (P94-30DG)

PDE6D Protein (P94-30DG)

  • $215.00


Description :Recombinant full-length human PDE6D was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :NM_002601

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :43 kDa

Gene Aliases :PDED; JBTS22

Scientific Background :PDE6D encodes the retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase subunit delta and is expressed in cells of the retinal rod and cone (1). PDE6D possesses the function to fornesylate, or prenylate or palmitoylate the membrane associated Ras and Rap GTPases to solubilize the target proteins (1,2). In addition, the solubilization activity of PDE6D is involved in the light adaption in the photoreceptors (1). Mutations in this gene have been identified as one cause of Joubert syndrome (3).

References :
1. Florio, S. K. et.al: Solubilization of Membrane-bound Rod Phosphodiesterase by the Rod Phosphodiesterase Recombinant δ Subunit. The Journal of Biological Chemistry. 39 (271): 24036–24047, 1996.

2. Nancy, V. et.al: The δ Subunit of Retinal Rod cGMP Phosphodiesterase Regulates the Membrane Association of Ras and Rap GTPases. The Journal of Biological Chemistry. 17 (227): 15076–15084, 2002.

3. Thomas S. et al. Homozygous PDE6D mutation in Joubert syndrome impairs targeting of farnesylated INPP5E protein to the primary cilium. Hum Mutat. 2014; 35(1): 137–146.

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Research Areas :Cardiovascular Disease, Inflammation, Phosphodiesterases