PLCB1 Protein (P441-30G)

PLCB1 Protein (P441-30G)

  • $348.00


Description : Recombinant full-length human PLCB1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species : Human

Tag : GST tag

Expression System : Sf9 insect cells using baculovirus

Sequence : Full Length

Genbank Number : NM_015192

Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications : Western Blot

Molecular Weight : 180 kDa

Gene Aliases : EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCB1A; PLCB1B

Scientific Background : 1-phosphatidylinositol 4, 5-bisphosphate phosphodiester-ase beta-1 (PLCB1) is one of the best characterized isoenzymes in the inositide specific phospholipase C (PI-PLC) family. Responsible for the hydrolysis of the phosphatidilinool-4, 5-bisphophate (PIP2), generating the second messengers inositol-1, 4, 5-triphosphate and di-acylglycerol. It is a key molecule for nuclear inositide signaling, where it plays a role in cell cycle progression, proliferation and differentiation.

References : 
1. Faenza I, et al: A role for PLCbeta1 in myotonic dystrophies type 1 and 2. Faseb J. 26:3042–3048, 2012.

2. Faenza I, et al: Nuclear inositide specific phospholipase C signalling - interactions and activity. FEBS J. 280(24):6311-21, 2013.

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Research Areas : Cancer, Cardiovascular Disease, Cellular Stress, Metabolic Disorder, Neurobiology,