Cantharidin (P16-902C)
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Description : Phosphatase PP2A Inhibitor
CAS Registry Number: 56-25-7
Molecular Formula : C10H12O4
Appearance : White powder
Molecular Weight : 196.20
Purity : >98% (HPLC)
Solubilization : May be dissolved in DMSO (20 mg/ml); or ethanol (5 mg/ml)
Aliases : 3α,7α-Dimethylhexahydro-4,7-epoxyisobenzofuran-1,3-dione
Storage and Stability : Store as supplied at -20oC for up to 2 years. Store solutions at -20oC for up to 2 weeks.
Scientific Background : Inhibits protein phosphatase 2A (Ki=0.19 uM) and PP1 (Ki=1.1 uM)1. Displays >500-fold selectivity over PP2B. Suppresses growth and migration of PANC-1 pancreatic cancer cells via phosphorylation and degradation of β-catenin2. Arrests G2/M transition via JNK/Sp1-dependent down-regulation of CDK13. Cell permeable.
References :
1. RE Honkanen FEBS Lett. 1993 330:283
2. MY Wu et al. Oncol. Rep. 2014 32:513
3. FR Gong et al. Oncotarget 2015 6:18469
Molecular Structure : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Product Sheets (By Lot #):
Research Areas: Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases,