Okadaic acid, free acid (P16-902)
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Description : PP2A and PP1 inhibitor
CAS Registry Number: 78111-17-8
Molecular Formula : C44H68O13
Appearance : White lyophilized solid
Melting Point : N/A
Molecular Weight : 805
Purity : >98% (TLC)
Solubilization : May be dissolved in DMSO (40 mg/ml); or Ethanol (5 mg/ml)
Aliases : None
Storage and Stability : Store as supplied at 4oC for up to 2 years. Store solutions at -20oC for up to 2 weeks.
Scientific Background : A naturally occurring polyether marine toxin. Potent and selective inhibitor of protein phosphatases inhibiting PP2A completely at 1nM and PP1 at higher concentrations, while PP2C is not inhibited. It is an extremely useful tool for studying cellular protein phosphorylation (2). Induces apoptosis in a variety of cell types (3). Activates atypical protein kinase isotypes and induces insulin-like effects in adipocytes (4).
References :
1. P Cohen et al. Trends Biochem. Sci.1990 15:98.
2. DG Hardie et al. Methods Ezymol.1991 201:469.
3. TJ Haneji et al. Int. J. Oncol. 2013 42:1904.
4. ML Standaert et al. J. Biol. Chem. 1999 274:14074.
Molecular Structure : Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Product Sheets (By Lot #):
Research Areas: Cancer, Cardiovascular Disease, Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder, Phosphatases, Ser/Thr Kinases,