OTUD7B, Active (O577-381G)
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Description : Recombinant human OTUD7B (1-482) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System : Sf9 insect cells
Sequence : 1-482
Genbank Number : NM_020205
Specific Activity : Sample Activity Plot. For specific information on a given lot, see related technical data sheet. 
Purity : Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications : Activity Assay, Western Blot
Molecular Weight : 81 kDa
Gene Aliases : CEZANNE, ZA20D1, OTU deubiquitinase 7B
Scientific Background : OUTD7B is a deubiquitinylase that belongs A20 subgroup of ovarian tumor (OUT) protein superfamily. It plays an essential role in inflammation and proliferation pathways. (1) OTUD7B is involved in regulation of the non-canonical NF-NF-κB pathway. (2) Studies suggest role of OUTD7B in cancer and has been shown to promote lung cancer cell proliferation and migration via Akt/VEGF signal pathway. Therefore, strategies to silence OTUD7B in carcinoma tissues may provide insights into developing therapies against lung adenocarcinoma and squamous carcinoma. (3)
References :
1. Cao L. et al. The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-kappaB pathway. J Cell Biochem. 119:1979–91 2018.
2. Hongbo H. et al. OTUD7B controls non-canonical NF-κB activation through deubiquitination of TRAF3. Nature. 494:371–374, 2013.
3. Dan-dan L. Upregulation of OTUD7B (Cezanne) promotes tumor progression via AKT/VEGF pathway in lung squamous carcinoma and adenocarcinoma. Frontiers in Oncology. 9:862, 2019.
Product Sheets: (by Lot #):
Research Areas : Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder