NPR2 Protein(N23-35G)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description :Recombinant human NPR2 (479-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :479-end
Genbank Number :NM_003995
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :86 kDa
Gene Aliases :AMDM; ANPB; ANPRB; GUC2B; GUCY2B; NPRB; NPRBi
Scientific Background :NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides which produce cytoplasmic cyclic GMP from GTP on binding its extracellular ligand, C-type natriuretic peptide (1).The granulosa cell ligand NPPC and its receptor NPR2 in cumulus cells prevent precocious meiotic maturation which is critical for maturation and ovulation synchrony and for normal female fertility. NPR2 is critical for the development of both bone and female reproductive organs (2).
References :
1. Lincoln, T. M.et.al: Intracellular cyclic GMP receptor proteins. FASEB J. 7: 328-338, 1993.
2. Tamura, N.et.al: Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc. Nat. Acad. Sci. 101: 17300-17305, 2004.
Product Sheets (By Lot #) :
Research Areas :Cardiovascular Disease, Cellular Stress, Neurobiology, Ser/Thr Kinases, Neurobiology, Cardiovascular Disease, Cellular Stress, Ser/Thr Kinases