LZK, Active (M21-11G)
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Description: Recombinant human LZK (1-427) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species: Human
Tag: N-Terminal GST tag
Expression System: Sf9 insect cells using baculovirus
Sequence: 1-427
Genbank Number :NM_004721
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at the recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~75 kDa
Gene Aliases : MAP3K13, MLK, MEKK13
Scientific Background : Leucine zipper-bearing kinase (LZK) is a member of MLK protein family that activates the c-Jun-NH2 terminal kinase pathway by acting as a mitogen‐activated protein kinase kinase kinase (MAPKKK) (1). LZK forms dimers/oligomers through its dual leucine zipper‐like motif that is required for activation of the JNK pathway. LZK has also been shown to activate NF‐κB‐dependent transcription through IKK activation. Antioxidant protein-1, a molecule found in the mitochondria, modulates the LZK‐induced NF‐κB activation (2).
References :
1. Ikeda, A. et. al: Identification and characterization of functional domains in a mixed lineage kinase LZK. FEBS Letters. 488(3):190-195, 2001.
2. Masaki, M. et. al: Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway. Eur. J. Biochem. 270, 76–83, 2003.
Product Sheets (By Lot #) :
Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cytoplasmic Tyrosine Kinases, Cancer, Cell Cycle, Ser/Thr Kinases, Cytoplasmic Tyrosine Kinases, Neurodegeneration, Neurobiology.