MEK5, Active (M06-10G)
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Description: Recombinant full-length human MEK5 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species : Human
Tag : GST tag
Expression System: Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :BC008838
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~77 kDa
Gene Aliases :MAP2K5, MAPKK5, MKK5, PRKMK5, SAPKK5; SKK5; HsT17454
Scientific Background :MEK5 or MAP2K5 (mitogen-activated protein kinase kinase 5) is a dual specificity protein kinase that belongs to the MAP kinase kinase family which specifically interacts with and activates MAPK7/ERK5. MEK5 itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by MEK5 is involved in growth factor stimulated cell proliferation and muscle cell differentiation (1). The rs3743354 polymorphism in the MEK5 promoter may affect the risk of developing colorectal cancer (CRC) (2).
References :
1. Zhou, G.et.al: Components of a new human protein kinase signal transduction pathway. J. Biol. Chem. 270: 12665-12669, 1995.
2. Diao. D. et.al: Mitogen/extracellular signal-regulated kinase kinase-5 promoter region polymorphisms affect the risk of sporadic colorectal cancer in a southern Chinese population. DNA Cell Biol. 2012 Mar; 31(3):342-9. doi: 10.1089/dna.2011.1232. Epub 2011 Aug 23.
Product Sheets (By Lot #) :
Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases