HDAC10, Active(H92-31G)

HDAC10, Active(H92-31G)

  • $226.00


Description :Recombinant human HDAC10 (1-482) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :1-482

Genbank Number :NM_032019

Specific Activity :Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :HDAC Assay, Western Blot

Molecular Weight :~77 kDa

Gene Aliases :DKFZp761B039; MGC149722

Scientific Background :HDAC10 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC10 belongs to class II of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the N-terminal tail of histones and represses transcription in large multiprotein complexes with transcriptional co-repressors (1). Therefore, HDAC10 plays a role in transcriptional repression. HDAC10 interacts with HDAC3 in co-transfected embryonic kidney cells (2). Deletion analysis indicates that both the N- and C-terminal domains of HDAC10 bound HDAC3 independently.

References :
1. Fischer, D. D. et.al: Isolation and characterization of a novel class II histone deacetylase, HDAC10. J. Biol. Chem. 277: 6656-6666, 2002.

2. Tong, J. J. et.al: Identification of HDAC10, a novel class II human histone deacetylase containing a leucine-rich domain. Nucleic Acids Res. 30: 1114-1123, 2002.

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