HDAC5, Active(H87-31G)

HDAC5, Active(H87-31G)

  • $226.00


Description :Recombinant mouse HDAC5 (617-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Mouse

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :617-end

Genbank Number :BC060609

Specific Activity :Sample Histone Deacetylase Activity Plot. For specific information on a given lot, see related technical data sheet.

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :HDAC Assay, Western Blot

Molecular Weight :~80 kDa

Gene Aliases :mHDA1; AI426555; mKIAA0600

Scientific Background :HDAC5 or Histone deacetylase 5 belongs to the class II histone deacetylase/acuc/apha family that possesses histone deacetylase activity and represses transcription when tethered to a promoter (1). HDAC 5 plays a critical role in transcriptional regulation, cell cycle progression, and developmental events and also acts as a potential therapeutic target for the prevention of atherosclerosis. HDAC5 can co-immunoprecipitates with HDAC3 family members forming multicomplex proteins. HDAC5 can also interact with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. HDAC5 gene is thought to be associated with colon cancer (2).

References :
1. Grozinger, C. M. et.al : Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc. Nat. Acad. Sci. 96: 4868-4873, 1999.

2. Scanlan, M. J. et.al: Characterization of human colon cancer antigens recognized by autologous antibodies. Int. J. Cancer 76: 652-658, 1998.

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