HTRA4 Protein(H534-31H)
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Description :Recombinant human HTRA4 (159-376) protein was expressed in E. coli cells using an N-terminal His-tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :159-376
Genbank Number :NM_153692
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~25 kDa
Gene Aliases :(None)
Scientific Background :HTRA1 is a serine protease with a conserved trypsin domain and a PDZ domain. As other related family members, HTRA4 may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. HrtA4 may contribute to shallow trophoblast invasion in preeclampsia (1) and imply a potential application as a biomarker for this disorder (2).
References :
1. Wang LJ. et.al: High-temperature requirement protein A4 (HtrA4) suppresses the fusogenic activity of syncytin-1 and promotes trophoblast invasion. Mol Cell Biol. 2012 Sep;32(18):3707-17.
2. Inagaki A. et.al: Upregulation of HtrA4 in the placentas of patients with severe pre-eclampsia. Placenta. 2012 Nov;33(11):919-26
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Research Areas :Cell Cycle, Neurobiology, Ser/Thr Kinases, Neurobiology, Cell Cycle, Ser/Thr Kinases