HTRA2 Protein(H532-31H)
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Description :Recombinant human HTRA2 (133-358) protein was expressed in E. coli cells using an N-terminal His-tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :133-358
Genbank Number :NM_013247
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :29 kDa
Gene Aliases :OMI; PARK13; PRSS25
Scientific Background :High temperature requirement protein A2 (HTRA2) is a serine protease that normally resides in mitochondrial membranes and plays a key role in the apoptosis pathways in different pathological conditions including myocardial ischemia/reperfusion injury. Heart ischemia /reperfusion induced HTRA2 translocation from the mitochondria to the cytosol promotes cardiomyocyte apoptosis via a protease activity-dependent and caspase-mediated pathway.
References :
1. Suzuki Y, et al: Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ 11:208–216. 2004
2. Bhuiyan MS, et al: Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury. Cardio-vasc Ther. 26(3):224-32. 2008
Product Sheets (By Lot #) :
Research Areas :Neurobiology, Cell Cycle, Ser/Thr Kinases