GAP43 Protein(G15-30H)
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Description :Full-length recombinant human GAP43 was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:E.coli
Sequence :Full length
Genbank Number :NM_002045
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~48 kDa
Gene Aliases :B-50; PP46
Scientific Background :Growth-associated protein 43 (GAP-43, also known as neuromodulin and B-50) mediates axonal growth, branching, and pathfinding during development. Plays a pivotal role both during development and in axonal remodeling in the adult brain. Increased expression observed in pathological or traumatic lesions induces neuronal rewiring.
References :
1. Grasselli G, et al: Structural plasticity of climbing fibers and the growth-associated protein GAP-43. Front Neural Circuits. 2013 Feb 21;7:25.
2. Oestreicher A. B., et al: (1997). B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system. Prog. Neurobiol. 53, 627–686.
3. Buffo A., et al: (2003). Extrinsic regulation of injury/growth-related gene expression in the inferior olive of the adult rat. Eur. J. Neurosci. 18, 2146–2158
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Research Areas :Cancer, Neurobiology