CREB1 Protein(C49-55G)
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Description :Recombinant rat CREB1 (1-280) was expressed in E. coli cells using a N-terminal GST tag.
Species :Rat
Tag :GST tag
Expression System:E.coli
Sequence :1-280
Genbank Number :NM_031017
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~59 kDa
Gene Aliases :Creb
Scientific Background :CREB1 is a member of the cAMP responsive element binding protein family of transcription factors that are critical mediators of gene expression in response to extracellular signals and are essential regulators of adaptive behavior and long-term memory formation (1). Activation of CREB1 by protein kinase A-mediated phosphorylation has been implicated in the survival of mammalian cells. Mice lacking CREB in the central nervous system during development show extensive apoptosis of postmitotic neurons (2). CREB binds as homo- and heterodimers to promoters containing CRE and activator protein 1 (AP-1) sites to alter target-gene expression).
References :
1. Valverde, O. et al: Modulation of anxiety-like behavior and morphine dependence in CREB-deficient mice. Neuropsychopharmacology. 2004 Jun; 29(6): 1122-33.
2. Mantamadiotis, T. et al: Disruption of CREB function in brain leads to neurodegeneration. Nat Genet. 2002 May; 31(1): 47-54.
Product Sheets (By Lot #) :
Research Areas :Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Invasion/Metastasis, Neurobiology, Inflammation, Metabolic Disorder, Cardiovascular Disease, ERK/MAPK Pathway, NfkB Pathway, PKA/PKC Pathway, Apoptosis/Autophagy, Invasion/Metastasis