CDK11/CyclinC Protein(C42-34G)

CDK11/CyclinC Protein(C42-34G)

  • $314.00


Description :Recombinant full-length human CDK11/CyclinC was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tags

Expression System:Sf9 insect cells using baculovirus

Sequence :Full length

Genbank Number :NM_015076

Genbank Number 2 :NM_005190

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Enzyme Assay, Western Blot

Molecular Weight :CDK11 ~92 kDa, and Cyclin H1 ~55 kDa

Gene Aliases :CDK11: CDC2L6; CDK8-like; bA346C16.3; KIAA1028
CyclinC: CCNC, CycC

Scientific Background :CDK11/Cyclin C is a member of the p34Cdc2 protein kinase family which are known to be essential for eukaryotic cell cycle control. CDK11/Cyclin C gene complex may harbor 1 or more tumor suppressor genes affected by chromosome 1p36 modifications in neuroblastoma (1). CDK11/Cyclin C expression is regulated during murine embryogenesis and its activity is coordinately regulated with that of p34 (cdc2) during the cell cycle (2).

References :
1. Lahti, J. M.. Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma. Nature Genet. 7: 370-375, 1994.

2. Bunnell, Elevated expression of a p58 protein kinase leads to changes in the CHO cell cycle. Proc. Nat. Acad. Sci. 87: 7467-7471, 1990. Note: Erratum: Proc. Nat. Acad. Sci. 88: 2612 only, 1991.

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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases