CDK13 (CDC2L) Protein(C25-35G)

CDK13 (CDC2L) Protein(C25-35G)

  • $215.00


Description :Recombinant human CDK13 (516-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST

Expression System:Sf9 insect cells using baculovirus

Sequence :516-end

Genbank Number :NM_003718

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~160 kDa

Gene Aliases :CDK13: CDC2L; CDC2L5; CHED; hCDK13

Formulation :50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Scientific Background :CDK13 or cyclin-dependent kinase 13 is a member of the cyclin-dependent serine/threonine protein kinase family which are well known for their essential roles as master switches in cell cycle control. CDK13 forms a complex with cyclin K and is predicted to play a role in gene regulation (1). CDK13 may play a role in mRNA processing and is thought to be involved in regulation of hematopoiesis (2). The CYCK-CDK12 and CYCK-CDK13 complexes display unique function in cell cycle and gene regulation.

References :
1. Blazek, The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25: 2158-2172, 2011.

2. Lapidot-Lifson, Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. Proc. Nat. Acad. Sci. 89: 579-583, 1992.

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Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases