CDK13/CyclinK Active (C25-11BG)

CDK13/CyclinK Active (C25-11BG)

  • $259.00


Description :Recombinant human CDK13 (516-end) /Cyclin K complex was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag on both proteins.

Species :Human

Tag :GST tags

Expression System:Sf9 insect cells using baculovirus

Sequence :CDK13 (658-end) and Cyclin K (Full Length)

Genbank Number : NM_003718

Genbank Number 2 : BC015935

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Specific Activity

Storage, Stability and Shipping : Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :  CDK13 approx. MW 160kDa and CyclinK Approx. MW 67kDa.

Gene Aliases :  CDK13: CDC2L; CDC2L5; CHED; hCDK13 CyclinK:  CCNK, CPR4, MGC9113

Scientific Background : CDK13 or cyclin-dependent kinase 13 is a member of the cyclin-dependent serine/threonine protein kinase family which are well known for their essential roles as master switches in cell cycle control. CDK13 forms a complex with cyclin K and is predicted to play a role in gene regulation (1). CDK13 may play a role in mRNA processing and is thought to be involved in regulation of hematopoiesis (2).  The CYCK-CDK12 and CYCK-CDK13 complexes display unique function in cell cycle and gene regulation.

References :

  1. Blazek, The cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes. Genes Dev. 25: 2158-2172, 2011.
  2. Lapidot-Lifson, Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. Proc. Nat. Acad. Sci. 89: 579-583, 1992.

Product Sheets (By Lot #) : J3908-7


Research Areas :Cancer, Cell Cycle, Ser/Thr Kinases, Cancer, Cell Cycle, Ser/Thr Kinases