AXIN1 Protein(A71-30G)

AXIN1 Protein(A71-30G)

  • $314.00


Description :Full-length recombinant human AXIN1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Species :Human

Tag :GST tag

Expression System:Sf9 insect cells using baculovirus

Sequence :Full Length

Genbank Number :BC044648

Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Applications :Western Blot

Molecular Weight :~135 kDa

Gene Aliases :AXIN; MGC52315

Scientific Background :AXIN 1 encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain that interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. AXIN1 has both positive and negative regulatory roles in Wnt-beta-catenin signaling. AXIN1 is a core component of a 'destruction complex' that promotes phosphorylation and polyubiquitination of cytoplasmic beta-catenin, resulting in beta-catenin proteasomal degradation in the absence of Wnt signaling. Nuclear accumulation of AXIN1 can positively influence beta-catenin-mediated transcription during Wnt signalling and can induce apoptosis (1). AXIN1 may be an effective therapeutic molecule for suppressing growth of hepatocellular and colorectal cancers (2).

References :
1. Lui, T. T. The ubiquitin-specific protease USP34 regulates axin stability and Wnt/beta-catenin signaling. Molec. Cell. Biol. 31: 2053-2065, 2011.

2. Satoh, AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genet. 24: 245-250, 2000.

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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, JNK/SAPK Pathway, WNT Signaling, Cancer, JNK/SAPK Pathway, WNT Signaling, Apoptosis/Autophagy, Cell Cycle