ACVR2B, Active (A36-11G)
FOR BULK ORDER REQUESTS PLEASE CONTACT US
Description: Recombinant human ACVR2B (182-488) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species: Human
Tag: N Terminal GST tag
Expression System: Sf9 insect cells using baculovirus
Sequence : 182-488
Genbank Number :NM_001106
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~61 kDa
Gene Aliases : ACTRII; ACVR2
Scientific Background : Activins are dimeric growth and differentiation factors belonging to the TGF-beta superfamily of structurally related signaling proteins that signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors (1). Activin receptor type-2B (ACVR2B) has been shown to regulate muscle growth (2), and is associated with visceral heterotaxy (3). ACVR2B is a transmembrane protein composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain with predicted serine/threonine specificity.
References :
1. Bondestam, J. et.al: Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. Cytogenet. Cell Genet. 87: 219-220, 1999.
2. Lee, S.-J. et.al: Regulation of muscle growth by multiple ligands signaling through activin type II receptors. Proc. Nat. Acad. Sci. 102: 18117-18122, 2005.
3. Kosaki R. et al: Left-right axis malformations associated with mutations in ACVR2B, the gene for human activin receptor type IIB. AM. J. Med. Genet. 82: 70-76, 1999.
Product Sheets (By Lot #) :
Research Areas :Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases, Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases