ACVR2A, Active(A35-11H)
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Description :Recombinant human ACVR2A (161-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag : His tag
Expression System:Sf9 insect cells using baculovirus
Sequence : 161-end
Genbank Number :NM_001616
Specific Activity :Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet. 
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~47 kDa
Gene Aliases : ACTRII; ACVR2
Scientific Background : Activins are dimeric growth and differentiation factors which belong to the TGF-beta superfamily of structurally related signaling proteins that signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors (1). ACVR2A is highly expressed in human brain and ovary and may be associated with susceptibility to preeclampsia (2). ACVR2A is a transmembrane protein, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain with predicted serine/threonine specificity.
References :
1. Donaldson, C. J. et.al: Molecular cloning and binding properties of the human type II activin receptor. Biochem. Biophys. Res. Commun. 184: 310-316, 1992.
2. Peng, C. et.al: Expression of the type II activin receptor gene in the human placenta. Endocrinology 133: 3046-3049, 1993.
Product Sheets (By Lot #) :
Research Areas :Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases, Cancer, Neurobiology, Cardiovascular Disease, ERK/MAPK Pathway, Apoptosis/Autophagy, Angiogenesis, Invasion/Metastasis, Ser/Thr Kinases