SOK1, Unactive(S43-14G)
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Description :Recombinant full-length human SOK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_006374
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.gif)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~74 kDa
Gene Aliases :STK25, YSK1, DKFZp686J1430
Scientific Background :SOK1 or oxidant stress-response kinase-1 is a serine/threonine kinase that is activated by autophosphorylation and by reactive oxygen intermediates, but is not activated by growth factors, alkylating agents, cytokines, or environmental stresses (1). SOK1 is expressed ubiquitously with highest expression in brain and testis. SOK1 regulates cell death after chemical anoxia, as its down-regulation by RNA interference enhances cell survival. SOK1 entry into the nucleus is important for the cell death response since SOK1 mutants unable to enter the nucleus do not induce cell death (2).
References :
1. Pombo, C M. et al: Activation of a human Ste20-like kinase by oxidant stress defines a novel stress response pathway. EMBO J. 15: 4537-4546, 1996.
2. Nogueira, E. et al: SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death. J Biol Chem. 2008 Jun 6; 283(23):16248-58.
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Research Areas :Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Cellular Stress, Inflammation, Neurobiology, Cancer, Neurobiology, Inflammation, Cardiovascular Disease, Apoptosis/Autophagy, Cellular Stress