USP7 (C-Term) Protein(U570-31G)
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Description :Recombinant human USP7 (560-end) was expressed in E.coli cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:E.coli
Sequence :560-end
Genbank Number :NM_003470
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot, Enzyme Function Tests, Enzyme Assay
Molecular Weight :94 kDa
Gene Aliases :HAUSP; TEF1
Scientific Background :USP7 (also called HAUSP) deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation.
References :
1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.
2. Rial, A. et al: Calcium Dyshomeostasis in β-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532
Product Sheets (By Lot #) :
Research Areas :Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder