UBE2W (UBC16) Protein(U240-30G)
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Description :Recombinant full length human UBE2W was expressed in E. coli cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :BC010900
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~45 kDa
Gene Aliases :hUBC-16; UBC-16; UBC16, FLJ11011
Scientific Background :UBE2W or ubiquitin-conjugating enzyme E2W (putative) encodes a nuclear-localized ubiquitin-conjugating enzyme (E2) (1). Ubiquitin-conjugating enzyme (E2) along with ubiquitin-activating (E1) and ligating (E3) enzymes coordinates the addition of an ubiquitin moiety to existing proteins. UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2 and may be important in the repair of DNA damage (2). UBE2W is highly expressed in heart, brain, liver, and pancreas.
References :
1. Yin, G. et.al: Cloning, characterization and subcellular localization of a gene encoding a human ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product. Front. Biosci. 11: 1500-1507, 2006.
2. Zhang, Y. et.al: UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2. Molec. Cells 31: 113-122, 2011.
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Research Areas :Neurobiology, Cell Cycle, Cancer