UBE2V2 Protein(U239-30H)
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Description :Recombinant human UBE2V2 (2-end) was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :2-end
Genbank Number :NM_003350
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~18 kDa
Gene Aliases :DDVit-1; DDVIT1; EDAF-1; EDPF1; MMS2; UEV-2; UEV2
Scientific Background :UBE2V2 or ubiquitin-conjugating enzyme E2 variant 2 constitutes a distinct subfamily within the E2 protein family which is critical for the catalytic activity of E2s and also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. UBE2V2 may be involved in the differentiation of monocytes and enterocytes (1). UBE2V2 functions in assembly of novel polyubiquitin chains for DNA repair (2).
References :
1. Fritsche, J.et.al: Molecular cloning of a 1-alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes. Biochem. Biophys. Res. Commun. 235: 407-412, 1997.
2. Hofmann, R. M.et.al: Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96: 645-653, 1999.
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Research Areas :Neurobiology, Cell Cycle, Cancer