UBA2 (SAE2) Protein(U202-30G)
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Description :Recombinant full-length human UBA2 (SAE2) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_005499
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~115 kDa
Gene Aliases :UBA2; UBLE1B; SAE2; ARX; HRIHFB2115
Scientific Background :UBA2 (SAE2) or ubiquitin-like modifier activating enzyme 2 forms a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins. The posttranslational modification of proteins by the addition of the small protein SUMO or sumoylation, regulates protein structure and intracellular localization (1). UBA2 functions in SUMO1 activation in a manner analogous to the single E1 ubiquitin-activating enzymes (2). The inactivation of UBA2 may be a therapeutic strategy in MYC-driven cancers.
References :
1. Okuma, T. et.al: In vitro SUMO-1 modification requires two enzymatic steps, E1 and E2. Biochem. Biophys. Res. Commun. 254: 693-698, 1999.
2. Desterro, J. et. al: Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1. J. Biol. Chem. 274: 10618-10624, 1999.
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Research Areas :Neurobiology, Cell Cycle, Cancer