TRIM32 Protein(T291-30G)
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Description :Recombinant human TRIM32 (2-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :2-end
Genbank Number :NM_012210
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~100 kDa
Scientific Background :BBS11; HT2A; LGMD2H; TATIP
Scientific Background :TRIM32 or tripartite motif containing 32 is a member of the tripartite motif (TRIM) family whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. TRIM32 localizes to cytoplasmic bodies and nucleus, where it interacts with the activation domain of the HIV-1 Tat protein that activates transcription of HIV-1 genes. TRIM32 is a regulator of dysbindin and mutations in TRIM32 may impair substrate ubiquitination (1). Deficiency of TRIM32 may involve both neurogenic and myogenic characteristics (2).
References :
1. Locke, M.et.al: TRIM32 is an E3 ubiquitin ligase for dysbindin. Hum. Molec. Genet. 18: 2344-2358, 2009.
2. Kudryashova, E.et.al: Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. Hum. Molec. Genet. 18: 1353-1367, 2009.
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Research Areas :Angiogenesis, Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Inflammation, Invasion/Metastasis, Neurobiology, Cancer, Metabolic Disorder