Moesin Protein(M52-55G)
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Description :Recombinant human Moesin (410-end) was expressed in E. coli cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:E.coli
Sequence :410-end
Genbank Number :NM_002444
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay, Western Blot
Molecular Weight :~50 kDa
Gene Aliases :MSN
Scientific Background :Moesin (or membrane-organizing extension spike protein) belongs to ERM family that modulates epithelial integrity by regulating cell-signalling events that affect actin organization and polarity (1). The effects of Moesin on epithelial cells appear to result from inhibition of Rho signaling. ERM proteins serve a structural role in linkage of the cytoskeletion to the plasma membrane and the rescue of cells lacking Moesin by modulation of Rho signaling indicates that inhibition of Rho activity may be a more critical function of Moesin. The negative feedback loop produced by Rho's activation of ERM may be an important mechanism that prevents the excessive migratory and invasive properties characteristic of metastatic cancer cells (2).
References :
1. Speck, O. et al: Moesin functions antagonistically to the Rho pathway to maintain epithelial integrity. Nature. 2003;421(6918):83-7.
2. Lankes, W.T. et akl: Moesin: a member of the protein 4.1-talin-ezrin family of proteins Proc. Natl. Acad. Sci. U S A. 1991;88(19):8297-301.
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Research Areas :Inflammation, PKA/PKC Pathway, Inflammation, PKA/PKC Pathway