TRIB3 Protein(T32-30G)
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Description :Recombinant full-length human TRIB3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_021158
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~69 kDa
Gene Aliases :NIPK, SINK, SKIP3, TRB3
Scientific Background :TRIB3 or tribbles homolog 3 protein encode one of three members of the Tribbles family that share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. TRIB3 is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. TRIB3 can negatively regulate the cell survival serine-threonine kinase AKT1. TRIB3 modulation by H. pylori and/or its products may be an important mechanism of H. pylori-associated pathogenesis (1). TRIB3 is a p65-interacting negative regulator of NF-kappa-B-dependent transcription (2). TRIB3 is highly expressed in pancreas, peripheral blood leukocytes, and bone marrow.
References :
1. Qi, L.et.al: TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism. Science 312: 1763-1766, 2006.
2. Wu, M. et.al: SINK is a p65-interacting negative regulator of NF-kappa-B-dependent transcription. J. Biol. Chem. 278: 27072-27079, 2003.
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Research Areas :Cancer, Metabolic Disorder, Cancer, Metabolic Disorder