Tau-361 Protein(T09B-54N)
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Description :Recombinant full-length Drosophila melanogaster tag-free Tau-361 was expressed in E. coli cells.
Species :Drosophila melanogaster
Tag :TAG-Free
Expression System:E.coli
Sequence :Full Length
Genbank Number :NM_143318.3
Alternative Name(s) :BcDNA:RE16764; CG12881; CG31057; CG31058; CG34294; CG45110; CG5606; d-tau; Dmel\CG45110; dTau; dTAU; Tau
Formulation :Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0,25mM DTT, 25% glycerol.
Formulation :Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0,25mM DTT, 25% glycerol.
Storage and Stability :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Scientific Background :Drosophila melanogaster Tau-361 and human Tau-441 are homologs with amino acid sequence similarities and share functional properties in microtubule binding and stability (1). Tau-361 exhibits 46% identity and 66% similarity with human Tau-441. Tau-361 contains five putative microtubule binding domain (MTBD) repeats, but does not contain the N-terminal MTBD repeats found in human Tau-441 (2). Drosophila melanogaster is a widely used powerful model organism utilized to investigate in vivo toxicity of proteins linked to neurodegenerative diseases, particularly Alzheimer’s disease where the accumulation of post-translationally modified Tau species leads to the formation of intracellular neurofibrillary tangles and subsequent neuronal death (1,2).
References :1. Burnouf, S. et al: Deletion of endogenous Tau proteins is not detrimental in Drosophila. Sci Rep. 2016; 6: 23102.
2. Heidary, G. and Fortini, M.E.: Identification and characterization of the Drosophila tau homolog. Mech. Dev. 2001; 108: 171-178.
Purity :
Molecular Weight :Observed MW ~53 kDa. Calculated MW ~41 kDa.
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Research Areas :Cancer, Cell Cycle