Stathmin Protein(S71-30H)
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Description :Recombinant full-length human Stathmin protein was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :BC014353
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~19 kDa
Gene Aliases :STMN1; C1orf215; FLJ32206; Lag; LAP18; MGC138869; MGC138870; OP18; PP17; PP19; PR22; SMN
Scientific Background :Stathmin is a ubiquitous, highly conserved protein present in the cytoplasm in a variety of unphosphorylated and phosphorylated forms. Stathmin functions as an intracellular relay integrating regulatory signals of the cellular environment (1). Stathmin is involved in the regulation of the microtubule filament system. Stathmin binds tubulin in a ternary complex, with 2 tubulins for every stathmin and this complex interferes with microtubule dynamics in vitro and in vivo. Overexpression of several stathmin mutants suggest that stathmin induces depolymerization of interphase and mitotic microtubules in its unphosphorylated state, but is inactivated by phosphorylation in mitosis (2).
References :
1. Sobel, A. Stathmin: a relay phosphoprotein for multiple signal transduction? Trends Biochem. Sci. 16: 301-305, 1991.
2. Gavet, O. et al: The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J. Cell Sci. 111: 3333-3346, 1998.
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Research Areas :Cancer, Invasion/Metastasis, Neurobiology, Cancer, Neurobiology, Invasion/Metastasis