STAT5B Protein(S56-54BH)
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Description :Recombinant full-length human STAT5B was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :His tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC065227
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~95 kDa
Gene Aliases :STAT5
Scientific Background :STAT5B or signal transducer and activator of transcription 5B is a member of the STAT family of transcription factors. STATs are phosphorylated by the receptor associated kinases and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT5B is activated in response to a variety of cytokines (1). The JAK/STAT pathway mediates a key signal from the somatic gonad that regulates male germline sexual development (2). STAT5B is critical for maintenance of tolerance in vivo and it is proposed that STAT5B is probably activated by IL2R.
References :
1. Wang, D.et.al: Naturally occurring dominant negative variants of Stat5.Molec. Cell Biol. 16: 6141-6148, 1996.
2. Wawersik, M.et.al: Somatic control of germline sexual development is mediated by the JAK/STAT pathway. (Letter) Nature 436: 563-567, 2005.
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Research Areas :Inflammation, ERK/MAPK Pathway, Cancer, JAK/STAT Pathway, Apoptosis/Autophagy