SETD4 Protein(S353-30G)
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Description :Full-length recombinant human SETD4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :BC002898
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :~62 kDa
Gene Aliases :C21orf18, C21orf27
Scientific Background :SET domain-containing protein 4 (SETD4) is a lysine methyltransferases that plays a crucial role in breast carcinogenesis. A correlation between high expression of SETD4 and a lack of the estrogen receptor (ER) in breast cancer was identified. SETD4 up-regulation is also associated with the proliferation of breast cancer cell line.
References :
1. Faria JA, et al: SET domain-containingProtein 4 (SETD4) is a Newly Identified Cytosolic and Nuclear Lysine Methyl-transferase involved in Breast Cancer Cell Proliferation. J Cancer Sci Ther. 2013 5(2):58-65.
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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology