SCYL3 Protein(S09-30G)
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Description :Recombinant human SCYL3 (2-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :2-end
Genbank Number :BC014662
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~110 kDa
Gene Aliases :PACE-1; PACE1; RP1-97P20.2
Scientific Background :SCYL3 encodes a protein with a kinase domain and four HEAT repeats which interact with the C-terminal domain of ezrin, an ERM protein which play a role in cell adhesion and migration (1). C-terminal domain of SCYL3 interacts with the C-terminal alpha-helical domain of ezrin. Biochemical assays indicate that SCYL3 had associated rather than intrinsic protein kinase activity. SCYL3 is associated with the cytoplasmic face of the Golgi apparatus. This distribution is dependent upon the presence of the SCYL3 N-terminal myristoylation consensus sequence but is not dependent on an association with ezrin. SCYL3 is highly expressed in breast carcinoma cells and adult colon.
References :
1. Sullivan, A. et.al: PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. Exp. Cell Res. 284: 224-238, 2003.
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Research Areas :Inflammation, Invasion/Metastasis, Neurobiology, Neurobiology, Inflammation, Invasion/Metastasis