SCYL2 Protein(S03-35G)
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Description :Recombinant human SCYL2 (1-520) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :1-520
Genbank Number :NM_017988
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~84 kDa
Gene Aliases :CVAK104, KIAA1360
References :
1. Borner GH. et.al: CVAK104 is a novel regulator of clathrin-mediated SNARE sorting. Traffic. 2007 Jul;8(7):893-903.
2. Miyakawa K. et.al: Interferon-induced SCYL2 limits release of HIV-1 by triggering PP2A-mediated dephosphorylation of the viral protein Vpu. Sci Signal. 2012 Oct 9;5(245):ra73. doi: 10.1126/scisignal.2003212
Scientific Background :SCYL2 or SCY1-like 2 (S. cerevisiae) is an evolutionarily conserved protein involved in SNARE sorting that is essential for normal embryonic development (1). SCYL2 serves as a regulatory factor for Vpu (viral protein U) which reducing the extent of Vpu phosphorylation and consequently enhancing BST2-mediated viral restriction (2).
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Research Areas :Inflammation, Invasion/Metastasis, Neurobiology, Neurobiology, Inflammation, Invasion/Metastasis