RGS1 Protein(R39-30H)
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Description :Recombinant full-length human RGS1 Protein was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :Full Length
Genbank Number :BC015510
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.gif)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~26 kDa
Gene Aliases :IR20, IER1, 1R20, BL34
Scientific Background :RGS1 is a member of the regulator of G-protein signalling family and attenuates the signalling activity of G-proteins. RGS1 binds to activated GTP-bound G alpha subunit and acts as a GTPase activating protein (GAP) thereby increasing the rate of conversion of GTP to GDP and terminating the signal (1). RGS1 is extensively up-regulated in renal cell carcinoma (RCC) tissues and melanoma. In melanoma, RGS1 expression is significantly correlated with increased tumor thickness, mitotic rate and presence of vascular involvement. Furthermore, there is significant association between increasing RGS1 expression and reduced relapse-free survival as well as disease-specific survival (DSS) survival (2).
References :
1. Sierra D A, et al: Evolution of the regulators of G-protein signaling multigene family in mouse and human. Genomics 79: 177-185, 2002.
2. Rangel J, et al: Novel role for RGS1 in melanoma progression. Am J Surg Pathol. 2008 Aug;32(8):1207-12
Product Sheets (By Lot #) :
Research Areas :AKT/PKB Pathway, Cancer, Cell Cycle, ERK/MAPK Pathway, Inflammation, JNK/SAPK Pathway, p38 Pathway, PKA/PKC Pathway, Cancer, Inflammation, AKT/PKB Pathway, ERK/MAPK Pathway, p38 Pathway, JNK/SAPK Pathway, PKA/PKC Pathway, Cell Cycle