Rel B Protein(R30-30H)
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Description :Recombinant full-length human Rel B was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_006509
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.gel.gif)
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~68 kDa
Gene Aliases :IREL, I-REL
Scientific Background :Rel B is part of the NFκB complex and forms heterodimeric complexes with p50 (NFKB1) and p52 (NFKB2) (1). The homodimeric complexes of Rel B alone do not show DNA-binding activity. IHC analysis has shown that Rel B expression correlated with dendritic cell activation. NFκB-inducing kinase NIK is required for osteoclastogenesis in response to pathologic stimuli and overexpression of Rel B rescues differentiation of mouse NIK -/- osteoclast precursors. Rel B is required for RANKL-induced osteoclastogenesis in vitro and for TNF -induced bone resorption in vivo. This indicates that the alternative NFκB pathway, via Rel B, plays an essential and unique role in RANKL signaling toward osteoclast development (2).
References :
1. Bours, V. et al: Human RelB (I-Rel) functions as a kappa-B site-dependent transactivating member of the family of Rel-related proteins. Oncogene 9: 1699-1702, 1994.
2. Vaira, S. Et al: RelB is the NF-kappa-B subunit downstream of NIK responsible for osteoclast differentiation. Proc. Nat. Acad. Sci. 105: 3897-3902, 2008
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Research Areas :Cancer, Neurobiology, Inflammation, NfkB Pathway, Apoptosis/Autophagy, Cancer, Neurobiology, Inflammation, NfkB Pathway, Apoptosis/Autophagy