RIPK4 Protein(R26-35G)
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Description :Recombinant human RIPK4 (15-426) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :15-426
Genbank Number :BC110618
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Kinase Assay
Molecular Weight :~57 kDa
Gene Aliases :ANKK2, DIK, PKK, RIP4, ANKRD3
Scientific Background :RIPK4 is a serine/threonine protein kinase that interacts with protein kinase C-delta which can also activate NFkappaB and is required for keratinocyte differentiation and it undergoes autophosphorylation. RIPK4 is a direct transcriptional target of p63, a known regulator of stratified epithelial development which acts as a nodal point in the cascade of molecular events that prevent pterygium syndromes (1). RIPK4 functions in the epidermis through PKC specific signaling pathways to regulate differentiation and inflammation (2).
References :
1. Mitchell, K.et.al: Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.Am. J. Hum. Genet. 90: 69-75, 2012.
2. Rountree, R. B.et.al: RIP4 regulates epidermal differentiation and cutaneous inflammation. J. Invest. Derm. 130: 102-112, 2010.
Product Sheets (By Lot #) :
Research Areas :Cancer, Inflammation, JAK/STAT Pathway, JNK/SAPK Pathway, p38 Pathway, Cancer, Inflammation, p38 Pathway, JNK/SAPK Pathway, JAK/STAT Pathway, Apoptosis/Autophagy, Ser/Thr Kinases