RIOK3 Protein(R06-34G)
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Description :Full-length recombinant human RIOK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :NM_003831
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~100 kDa
Gene Aliases :SUDD
Scientific Background :RIOK3 or RIO kinase 3 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells which is required for normal processing of the 21S pre-rRNA (1). RIOK3 is identified by the similarity of its product to the Aspergillus nidulans SUDD protein, an extragenic suppressor of the heat-sensitive bimD6 mutation that fails to attach properly to the spindle microtubules at a restrictive temperature. RIOK3 is highly expressed in human tissues, with additional smaller transcripts present in testis (2).
References :
1. Fenner BJ. et.al: Human RioK3 is a novel component of cytoplasmic pre-40S pre-ribosomal particles. 162-74. doi: 10.4161/rna.18810. Epub 2012 Feb 1.
2. Anaya, P.et.al: Isolation of the Aspergillus nidulans sudD gene and its human homologue. Gene 211: 323-329, 1998.
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Research Areas :AKT/PKB Pathway, Cancer, Ser/Thr Kinases, Cancer, AKT/PKB Pathway, Ser/Thr Kinases