RIOK1 Protein(R04-34G)
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Description :Full-length recombinant human RIOK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full Length
Genbank Number :BC006104
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~110 kDa
Gene Aliases :AD034; RRP10; bA288G3.1; FLJ30006; MGC12903
Scientific Background :RIOK1 or RIO kinase 1 is a novel cytoplasmic component of pre-40S pre-ribosomal particle(s) in human cells which is required in the final stages of cytoplasmic pre-40S maturation (1). RioK1 is a new interactor of protein arginine methyltransferase 5 (PRMT5) which competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity (2). RIOK1 may reveal new insights into defects underlying glioblastoma and related cancers and may reveal new therapeutic opportunities for these cancers.
References :
1. Widmann B. et.al: The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits. Mol Biol Cell. 2012 Jan;23(1):22-35. doi: 10.1091/mbc.E11-07-0639. Epub 2011 Nov 9.
2. Guderian G1. et.al: RioK1, a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. J Biol Chem. 2011 Jan 21;286(3):1976-86. doi: 10.1074/jbc.M110.148486. Epub 2010 Nov 16.
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Research Areas :AKT/PKB Pathway, Cancer, Ser/Thr Kinases, Cancer, AKT/PKB Pathway, Ser/Thr Kinases