PXK Protein(P99-35G)
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Description :Full-length recombinant human PXK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :Full length
Genbank Number :NM_017771
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~90 kDa
Gene Aliases :FLJ20335; MONaKA
Scientific Background :PX Domain Containing Serine/Threonine Kinase (PXK) is involved in synaptic transmission through modulating brain Na,K-ATPase subunits ATP1B1 and ATP1B3 participate in the ligand-induced internalization and degradation of epidermal growth factors. Mutation of this gene may be associated with susceptibility to systemic lupus erythematosus (SLE).
References :
1. Takeuchi H, et al. Characterization of PXK as a protein involved in epidermal growth factor receptor trafficking. Mol Cell Biol. 30:1689-702, 2010.
2. Zou X, et al. Expression pattern and subcellular localization of five splice isoforms of human PXK. Int J Mol Med. 16:701-7, 2005 Oct.
Product Sheets (By Lot #) :
Research Areas :Ser/Thr Kinases, Inflammation