PRDM2 (KMT8) Protein(P333-31G)
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Description :Recombinant PRDM2 (KMT8) (1-340) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Species :Human
Tag :GST tag
Expression System:Sf9 insect cells using baculovirus
Sequence :1-340
Genbank Number :NM_012231
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Methyltransferase Assay
Molecular Weight :80 kDa
Gene Aliases :HUMHOXY1; KMT8; MTB-ZF; RIZ; RIZ1; RIZ2
Scientific Background :PRDM2 is a histone methyltransferase that specifically methylates lysine-9 of histone H3. PRDM2 is a retinoblastoma protein-interacting zinc finger protein and a tumor suppressor. Loss of PRDM2 activity through loss of mRNA expression, frameshift, deletion, and missense mutation is commonly found in many types of human cancers (1, 2).
References :
1. Du, Y., et al. Hypermethylation in human cancers of the RIZ1 tumor suppressor gene, a member of a histone/protein methyltransferase superfamily. Cancer Res. 61(22):8094-9, 2001.
2. Kim, K.C., et al. Inactivation of a histone methyltransferase by mutations in human cancers. Cancer Res. 63(22):7619-23, 2003.
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Research Areas :Cancer, Neurobiology