PARK7 (DJ-1) Protein(P219-31H)
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Description :Recombinant human PARK7 (DJ-1) (19-end) was expressed in E. coli cells using an N-terminal His tag.
Species :Human
Tag :HIS tag
Expression System:E.coli
Sequence :19-end
Genbank Number :NM_007262
Purity :Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping :Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Applications :Western Blot
Molecular Weight :~22 kDa
Gene Aliases :PARK7; DJ-1; DJ1
Scientific Background :PARK7 or parkinson protein 7 belongs to the peptidase C56 family of proteins which acts as a positive regulator of androgen receptor-dependent transcription. PARK7 also functions as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. PARK7 mutations that impair transcriptional co-activator function can render dopaminergic neurons vulnerable to apoptosis and may contribute to the pathogenesis of Parkinson disease (1). PARK7 is an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide through oxidation of cys106 (2).
References :
1. Xu, J.et.al: The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum. Molec. Genet. 14: 1231-1241, 2005.
2. Andres-Mateos.et.al: DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase. Proc. Nat. Acad. Sci. 104: 14807-14812, 2007.
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Research Areas :Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology, Cancer, Neurobiology, Apoptosis/Autophagy, Cell Cycle